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However, one of the major drawbacks of this study was the lack of a control or placebo group (38). Further well-controlled studies are therefore required to examine the long-term effects of curcumin against rheumatoid arthritis. In another recent study, curcumin alone (0. Furthermore, the level of CRP was suppressed in these patients after curcumin administration (Fig. Another study in 50 patients with osteoarthritis evaluated the efficacy of Meriva at a dose that corresponded to 200 mg of curcumin per day (40). The signs and symptoms of osteoarthritis were evaluated with use of WOMAC scores, an indicator of pain level. The mobility was assessed by walking performance (treadmill), and inflammatory status was assessed by measuring the levels of CRP. In comparison, only modest improvement in these measurements was observed in the control group. Overall, these results suggested the efficacy of Meriva in the management of osteoarthritis (40). In a subsequent study, this group investigated the long-term efficacy and safety of Meriva in a longer (8-month) study involving 100 patients with osteoarthritis (41). The need for hospital admissions, consultations, and tests by the patients was also decreased after Meriva treatment. The authors of this study concluded that Meriva is skiing gloves considering for the long-term complementary management of osteoarthritis (41). Uveitis is an inflammation of the uvea, the middle layer of the eye. Depending on the anatomical localization and visible signs of the disease, uveitis can be classified into anterior, posterior, pan, and intermediate. Corticosteroids are normally used for treatment of uveitis. However, the adverse effects associated with these drugs limit their use. One study evaluated the efficacy of curcumin against chronic anterior uveitis (42). Curcumin was administered orally to patients with chronic anterior uveitis at a dose of 375 mg three times a day for 12 weeks. Of 53 patients enrolled, 32 completed the 12-week study and were divided into two groups. One group of 18 patients Get Cheap Mermaid Tails curcumin alone, whereas the other group of 14 patients, who had a strong reaction to tuberculin purified protein derivative, also received anti-tubercular treatment. After 2 weeks of treatment, both groups showed significant improvement in the disease. The efficacy of curcumin on recurrences after treatment was comparable to that of corticosteroid therapy. Furthermore, lack of any adverse effects with curcumin was an advantage over corticosteroid therapy (42). A double-blind, multicenter clinical trial with curcumin against chronic anterior uveitis is highly desirable to further validate the results of this study. One nonplacebo-controlled study evaluated the efficacy of Meriva against recurrent anterior uveitis (43).
The study group consisted of 106 patients divided into three main groups of different uveitis origin: group 1 (autoimmune uveitis, 56 patients), group 2 (herpetic uveitis, 28 patients), and group 3 (various etiologies of uveitis, 22 patients). The primary end point was relapse frequency in all treated patients, before and after Meriva treatment, followed by the number of relapses in the three etiological groups. The secondary end points were relapse severity and overall quality of life. A total of 106 and 19 patients, respectively, had relapses before and after treatment with Norflo. Furthermore, the total number of relapses was reduced from 275 to 36 after the 1-year treatment with Norflo. Thus, the study demonstrated the therapeutic role of curcumin and its efficacy against recurrent anterior uveitis (43). After surgery, patients were randomly assigned to receive curcumin (400 mg), placebo (250 mg lactose powder), or phenylbutazone (100 mg) three times a day for 6 days. Spermatic cord edema, spermatic cord tenderness, operative site pain, and operative site tenderness reflected by intensity score (TIS) were measured. TIS on day 6 decreased by 84. Although TIS values for the curcumin and phenylbutazone groups were similar on day 6, curcumin proved to be superior by reducing all four measures of inflammation (44). Peptic ulcers are the most common ulcer of the gastrointestinal tract and can be extremely painful. These ulcers are usually open sores that develop on the inner lining of the esophagus, stomach, and the upper portion of the small intestine. If the peptic ulcer is located in the stomach, it is called a gastric ulcer. The preferred medications for peptic ulcers include proton pump inhibitors, histamine receptor blockers, and antibiotics to kill a Helicobacter pylori infection. A randomized controlled clinical trial from Thailand compared the efficacy of turmeric and liquid antacid (containing 333 g of aluminum hydroxide and 33.
Of the 60 patients who participated in the study, 30 received turmeric (250 mg, four times per day), and the other 30 received antacid (30 ml, four times per day). The treatment was continued for 6 to 12 weeks. Although both antacid and turmeric improved gastric ulcers in patients, the former was better in reducing the ulcers (45). A phase II clinical trial from Thailand evaluated the safety and efficacy of curcumin in patients with peptic ulcers (46). Twenty-five patients (18 men pandora starter set 7 women) underwent endoscopy, and their ulcers were found in the duodenal bulb and gastric (angulus) region. The remaining 20 patients did not have ulcers but appeared to have erosions, gastritis, and dyspepsia. Two capsules (300 mg each) of turmeric were given orally five times daily over a period of 4 weeks. The remaining patients had symptomatic relief after turmeric treatment (46). The bacterium is also involved in the pathogenesis of several other diseases, such as mucosa-associated lymphoid tissue lymphoma, gastric adenocarcinoma, iron deficiency anemia, skin disease, and rheumatologic conditions (87). The most commonly used treatment regimens for H.